Textbook of Diabetes and Pregnancy,4th Edition

Written by a cadre of experts, this new edition provides a comprehensive, authoritative, and international view of gestational diabetes mellitus and will be invaluable to maternal-fetal medicine specialists, diabetologists, neonatologists, and a growing number of gynecologists and general physicians concerned with the management of noncommunicable diseases in pregnancy.

• Offers a comprehensive and authoritative guide to all aspects of the subject internationally
• Presents an invaluable resource for all working in diabetes, maternal-fetal medicine, and obstetrics
• Shows the latest developments in research in genomics and in practice with the digital clinic

In Memoriam: Oded Langer† by Yariv Yogev

Honoring Lois Jovanovič (1947–2018) by Alejandra de Leiva-Pérez and Alberto de Leiva-Hidalgo

Preface

List of Contributors

1 Prologue: Maternal Medicine Meets Fetal Medicine: Merging the Legacies and Hypotheses

Moshe Hod, Kypros Nicolaides, Hamutal Meiri, and Nicky Lieberman

2 History of Diabetic Pregnancy

David R. Hadden†, Alejandra de Leiva-Perez, and Alberto de Leiva-Hidalgo

3 Epidemiology of Gestational Diabetes Mellitus

Yariv Yogev, Avi Ben Haroush, Moshe Hod, and Jeremy Oats

4 The Great Obstetric Syndromes: The Roots of Disease

Rinat Gabbay-Benziv and Ahmet A. Baschat

5 Metabolism in Normal and in Diabetic Pregnancy

Emilio Herrera and Henar Ortega-Senovilla

6 Nutrient Delivery and Metabolism in the Fetus

William W. Hay

7 Pathogenesis of Gestational Diabetes Mellitus

Yariv Yogev

8 Autoimmunity in Gestational Diabetes Mellitus

Alok Kumar, Lilian C. Mendoza, Didac Mauricio, Rosa Corcoy, and Alberto de Leiva-Hidalgo

9 The Placenta in Diabetic Pregnancy

Laura Avagliano, Margaret Mascherpa, and Gaetano Bulfamante

10 Gestational Diabetes Mellitus: The Consequences of Not Treating

Oded Langer†

11 Implications of Diabetic Pregnancy: The Offspring

Kit Ying Tsoi, Wing Hung Tam, and Ronald Ching Wan Ma

12 Short-Term Implications: The Neonate

Paul Merlob, Sharon Hod, and Moshe Hod

13 Implications of Diabetic Pregnancy: The Mother

Garry X. Shen and Kaberi Dasgupta

14 Gestational Diabetes Mellitus, Obesity and Pregnancy Outcomes

Gillian A. Corbett and Fionnuala M. McAuliffe

15 Hypertensive Disorders and Diabetic Pregnancy

Lo Wong, Melanie Nana, and Liona C. Poon

16 Fetal Congenital Malformations in Diabetic Pregnancy

Conrado Savio Ragazini, Cristiane de Freitas Paganoti, Conrado Milani Coutinho, and Fabricio da Silva Costa

17 Post-Implantation Diabetic Embryopathy

Ulf J. Eriksson and Parri Wentzel

18 Congenital Malformations in Diabetic Pregnancy: Prevalence and Types

Paul Merlob

19 Reproduction and Its Impact on Health and Disease

Sara Ornaghi and Michael J. Paidas

20 Prediction and Prevention of Gestational Diabetes Mellitus

Harold David McIntyre

21 Inositols and Prevention of Gestational Diabetes Mellitus

Fabio Facchinetti, Serena Lecis, and Pierluigi Di Vinci

22 The Multiomics Approach to Diabetes in Pregnancy

Abraham Tsur

23 The Role of Bariatric Surgery in Obese Women Planning Pregnancy

Ron Charach, Tifferet Willner, and Eyal Sheiner

24 The Role of Glucagon-Like Peptide-1 (GLP-1) in Women with Obesity Planning Pregnancy

Yoel Toledano and Moshe Hod

25 Diagnosis of Gestational Diabetes Mellitus

Federico Mecacci, Serena Ottanelli, and Giorgio Mello

26 Glucose Intolerance in Pregnancy: A Window to Mother and Offspring Future Cardio-Metabolic Risk

Maya Karen Nitecki and Gilad Twig

27 Ideal Weight Gain in Pregnancy with Diabetes

Gillian A. Corbett and Fionnuala M. McAuliffe

28 Glycemic Goals in Diabetic Pregnancy and Defining "Good Control": Maternal and Fetal Perspective

Tomer Avnon, Yariv Yogev, and Liran Hiersch

29 Medical Nutritional Therapy for Gestational Diabetes Mellitus

Alejandra de Leiva-Perez, Lois G. Jovanovič†, and Alberto de Leiva-Hidalgo

30 Insulin Therapy in Pregnancy

Lene Ringholm, Sidse Kjarhus Norgaard, and Elisabeth R. Mathiesen

31 Use of Non-Insulin Antihyperglycemic Drugs in Relation to Pregnancy

Montserrat Balsells, Apolonia Garcia-Patterson, and Rosa Corcoy

32 Continuous Subcutaneous Insulin Infusion and Continuous Glucose Monitoring in Pregnancy

Eytan Roitman

33 Periconceptional Assessment in Diabetic Women Planning Pregnancy

Elisabetta Torlone and Annunziata Lapolla

34 Early Pregnancy Loss and Perinatal Mortality

Mariane Silve Edge and Hassan Shehata

35 Fetal Surveillance in Diabetic Pregnancies

Monica Centeno and Diogo Ayres-de-Campos

36 Timing and Mode of Delivery in Diabetic Pregnancy

Rodney McLaren Jr. and Vincenzo Berghella

37 Management of the Macrosomic Fetus: Can Fetal Macrosomia Be Predicted and Prevented?

Federico Mecacci, Marianna Pina Rambaldi, and Giorgio Mello

38 Gestational Diabetes in Twin Pregnancies

Nir Melamed and Liran Hiersch

39 Fetal Growth Restriction in Diabetic Pregnancies

Sharon Alpern, Isca Landesberg, Nir Melamed, and Liran Hiersch

40 Diabetes, Obesity, Hypertension, and Preterm Birth

Ann Rowan and Michael Geary

41 Diabetic Retinopathy

Jennifer Fu, Ilana Halperin, and Nir Melamed

42 Diabetic Kidney Disease

Lene Ringholm, Nicoline Callesen-Do, Marianne Jenlev Vestgaard, Peter Damm, and Elisabeth R. Mathiesen

43 Diabetic Ketoacidosis

Annunziata Lapolla, Giovanni Sartore, and Maria Grazia Dalfrà

44 Thyroid In Pregnancy

Yoel Toledano

45 Gestational Diabetes in Lower- and Middle-Income Countries

Hema Divakar, Anne Beatrice Khiara, and Moshe Hod

46 Managing Diabetic Pregnancy in China

Chen Wang, Rina Su, and Huixia Yang

47 Links between Maternal Health and Noncommunicable Diseases

Anil Kapur

48 Diabetes, Pregnancy, and the Developmental Origins of Health and Disease

Gerard H.A. Visser and Mark A. Hanson

49 Postpartum Management: Mother and Offspring

Shayna Miodownik, Omri Zamstein, and Eyal Sheiner

50 Non-Invasive Glucose Monitoring

Eran Hadar and Moshe Hod

51 Closed-Loop Insulin Delivery in Type 1 Diabetes Pregnancy

Zoe A. Stewart and Helen R. Murphy

52 Epilogue: Maternal Fetal Medicine Meets Femtech while Digitalizing Pregnancy Management: Present and Future

Moshe Hod, Hema Divakar, Anne Beatrice Kihara, and Michael Geary

Index