Recurrent Pregnancy Loss Causes, Controversies and Treatment,3rd Edition

Part I: Basic Principles

1 The Epidemiology of Recurrent Pregnancy Loss

Ole B. Christiansen

2 The Signaling between Embryo and Mother as a Basis for the Development of Tolerance

Eytan R. Barnea

3 Recurrent Pregnancy Loss: From Evidence-Based to Personalized Medicine

Howard J.A. Carp

Part II: Etiology

4 The Genetics of Spontaneous Abortions

Joe Leigh Simpson

5 The Endometrial Factor in Recurrent Pregnancy Loss

Luiza Borges Manna and Ying Cheong

6 Fetal Structural Malformations and Recurrent Pregnancy Loss

Howard J.A. Carp, Tomas Philipp, Micha Baum, and Michal Berkenstadt

7 The Endocrinology of Recurrent Pregnancy Loss

Nicola Pluchinoi, Serena Bellaminutti, Panagiotis Drakopoulos, Antonis Makrigiannakis, and Andrea R Genazzani

8 The Etiology of the Antiphospholipid Syndrome

Sara De Carolis, Giuseppina Monteleone, Rotem Inbar, Cristina Garufi, Miri Blank, and Yehuda Shoenfeld

9 Defects in Coagulation Factors Leading to Recurrent Pregnancy Loss

Aida Inbal and Howard J.A. Carp

10 The Immunobiology of Recurrent Miscarriage

Marighoula Varla-Leftherioti. Theodora Keramitsoglou, and Christina Tsekoura

11 Immune Testing in Recurrent Pregnancy Loss

Jeffrey Braverman, Darren Ritsick, and Nadera Mansouri-Attia

12 Uterine Anomalies andRecurrent Pregnancy Loss

Daniel S. Seidman and Mordechai Goldenberg

13 The Male Factor in Recurrent Pregnancy Loss

Catherine F. Ingram, Nannan Thirumavalavan, Marc Goldstein, and Delores J. Lamb

Part III: The Developing Pregnancy

14 Ultrasound Follow-Up in Early Pregnancy

Akhila Vasudeva and Pratap Kumar

15 Threatened Miscarriage and Recurrent Pregnancy Loss

Howard J.A. Carp

16 The Role of Cerclage and Pessaries

Israel Hendler and Howard J.A. Carp

17 What Genetic Screening Is Appropriate in Recurrent Pregnancy Loss?

Howard Cuckle

18 Obstetric Outcomes after Recurrent Pregnancy Loss

Rakefet Yoeli-Ullman, Howard J.A. Carp, and Shali Mazaki-Tovi

Part IV: Management

19 Investigation Protocol for Recurrent Pregnancy Loss

Howard J.A. Carp

20 Debate: Should Progestogens Be Used in Recurrent Pregnancy Loss? Yes

Ashok Kumar and Simar Kaur

21 Debate: Should Progestogens Be Used in Recurrent Pregnancy Loss? No

Roy Mashiach

22 Human Chorionic Gonadotropin Supplementation in Recurrent Pregnancy Loss

Carlo Ticconi, Adalgisa Pietropolli, and C.V. Rao

23 Antiphospholipid Syndrome: Management of the Obstetric Patient

Ashley E. Benson and D. Ware Branch

24 Can Recurrent Pregnancy Loss Be Prevented by Antithrombotic Agents?

Audrey A. Merriam and Michael J. Paidas

25 Empirical In Vitro Fertilization for Recurrent Pregnancy Loss: Is It a Valid Concept?

Michal Kirshenbam and Raoul Orvieto

26 Debate: Should PGT-A Still Be Performed in Recurrent Pregnancy Loss? Yes

Carmen M. Garcia-Pascual, Pilar Lopez, Nasser Al-Asmar, Pere Mir, Lorena Rodrigo, Carlos Simon, and Carmen Rubio

27 Debate: Should PGT-A Still Be Performed in Recurrent Pregnancy Loss? No

Raoul Orvieto and Norbert Gleicher

28 Third Party Reproduction in Recurrent Pregnancy Loss

Gautam Nand Allahbadia, Rubina Merchant, Akanksha Allahbadia Gupta, and A.H. Maham

Part V: Immunotherapy

29 Immunotherapy for Recurrent Pregnancy Loss

Salim Daya

30 IVIg treatment for Recurrent Pregnancy Loss

Carolyn B. Coulam

31 The Role of Filgrastrim

Fabio Scarpellini and Marco Sbracia

32 Opinion: Immunotherapy Has No Place in the Treatment of Recurrent Pregnancy

Loss

Micha Baum