Cannabis Use, Neurobiology, Psychology, and Treatment I. Setting the scene and introductory chapters 1. Metabolomics of the cannabis plant Mickel Hiebert-Giesbrecht, Claudia Torres-Calzada and David Scott Wishart 2. The roots of Cannabis sativa: chemical and pharmacological profile L A. Rolim 3. Cannabis related compounds in beverages and food Ilaria Di Marco Pisciottano 4. The impact of prenatal cannabis exposure: an overview Natalia Kleinhans 5. Cannabinoid Genotoxicity and Congenital Anomalies: A Convergent Synthesis of European and USA Datasets Albert Stuart Reece and Gary K. Hulse 6. Cannabis Genotoxicity and Cancer Incidence: A Highly Concordant Synthesis of European and USA Datasets Albert Stuart Reece and Gary K. Hulse 7. Cannabis, Cognitive impairment and Car Crash risk U.W. Preuss II. Cannabis usage 8. Recreational cannabis use: a French perspective of adverse effects Emilie Bouquet, Emilie Jouanjus and Maryse Lapeyre-Mestre 9. Acute and chronic impact of cannabis on human cognition Justin Matheson and Bernard Le Foll 10. Polydrug users, use of cannabidiol (CBD) and abuse potential/Polydrug users, use of cannabinoids and abuse potential Kerri Alexandra Schoedel 11. Cannabis stigmas: a narrative of features Matt Reid 12. Alterations of THC and CBD ratios and impact on cognition Erica Zamberletti 13. When cannabis is used for medicinal purposes: a focus on back pain R. L. Price III III. Pharmacological and Physiological Aspects 14. Cannabis, cannabinoids and receptor responses Yi Yang, Roya Derwish and Lakshmi P. Kotra 15. Cannabidiol (CBD): abuse potential and withdrawal Kenneth W. Sommerville and Beatrice Setnik 16. 4,5- Dihydro-1H-pyrazole/3,4-Diarylpyrazoline class of cannabinoid-1 (CB1R) receptor antagonists and their potential in medicinal applications Malliga R. Iyer IV. Neurobiology of cannabis 17. Neurobiology of cannabis Rohit Goyal and Deepak Kumar 18. The kynurenine pathway, neurobiology and cannabis misuse: a new narrative Nuria Morales-Puerto and Esther O`Shea 19. Central nervous system cancers and use of cannabis and related products: an updated narrative J. Eduardo Rodriguez Almaraz and Nicholas Butowski 20. Chronic cannabis users: links with glutamate and resting state connectivity S.D. Newman 21. Brain metabolic responses to cannabis use in people with multiple sclerosis: Insights from [18F]-FDG positron emission tomography and functional MRI Thorsten Rudroff 22. Genetic Variation and Acute Responses to Cannabis Bernard Le Foll, Zoe Bourgault and Justin Matheson 23. Cell Signaling of the CB1 Cannabinoid Receptor via beta-arrestins, Cannabinoid Receptor Interacting Protein (CRIP1a) and other regulatory proteins Allyn C. Howlett 24. Cannabis and impact on memory: from in utero to adults Jennifer Willford, Meaghan Hazelet, Mohamad Khalaifa, Natacha DeGenna and Gale A. Richardson 25. Central CB1 receptors and age-related changes: investigating the effects of DELTA-9-tetrahydrocannabinol Brett C. Ginsburg and Hanana AlTfaili 26. Alcohol, cannabis and visual memory Concepcion Vinader-Caerols V. Neurobiology of cannabinoids 27. The role of Delta-FosB in the plasticity of the cannabinoid system Arturo Venebra-Munoz and Sara Mejía-Chávez 28. Functional profile of synthetic cannabinoid receptor agonists: exploring cannabinoid and non-cannabinoid targets Shivani Sachdev, Marina Santiago and Chris Bladen 29. Linking the G protein-coupled orphan receptor GPR55 to the cannabinoid receptors (CB1 and CB2): a new narrative Paula Morales, Raquel Guerrero-Alba and B.A. Marichal-Cancino 30. Proteomic analysis of cannabinoids in human oligodendrocytes Valéria Almeida 31. Cannabinoids and endocannabinoid signaling at the basal forebrain cholinergic system Rafael Rodriguez 32. Cannabidiol (The major non-psychotropic cannabinoid in the cannabis plant) and the PI3K/Akt pathway in the CNS Nadja Schroder 33. Effects of cannabidiol and other phytocannabinoids on ion channels Murat Oz, Keun-Hang Susan Yang, Mohamed Mahgoub, Georg Petroianu and Dietrich Lorke 34. Cannabis, neurodevelopment and the "two-hit hypothesis" Elisa Guma, Lani Cupo and Mallar Chakravarty VI. New and synthetic cannabinoids 35. Impact of tetrahydrocannabinol (THC ) and synthetic "spice"cannabinoids on nicotine use and abuse Christie Dawn Fowler and Angeline Dukes 36. Synthetic cannabinoids: how do they compare to DELTA9-tetrahydrocannabinol: neurological effects and beyond Chris S. Breivogel VII. Biomarkers, analysis and screening 37. The DSM-5 criteria of cannabis use disorder: methods and applications Mahadev Sen, Siddharth Sarkar and Yesh Singh 38. Cannabis and clinical high risk for psychosis: monitoring and smartphones Jean Addington VIII. Impact on non-neurological systems 39. The impact of cannabis and cannabinoids on the skin Jane M. Grant-Kels 40. Cannabis consumption in reproduction and teratogenicity Susana Sa and B.M. Fonseca 41. Cannabis compounds and putative cytotoxicity: profile of cancer cells Hadar Peeri and Hinanit Koltai IX. Treatments, strategies and resources 42. Motivational Interviewing for Cannabis Use Disorders: a narrative review from research to practice Hugo López-Pelayo, Maria Teresa Pons-Cabrera, Clara Oliveras Salvà and Pablo Rodrigo Guzmán Cortez 43. An Overview of Current Pharmacologic Interventions for Management of Cannabis Withdrawal and the Evidence for Their Use David Wolinsky 44. Managing cannabinoid hyperemesis syndrome in paediatrics: A new narrative review Justin P. Reinert 45. Gabapentinoids for the Treatment of Cannabis Use Disorder: A Focus on Human Laboratory Research Joshua A. Lile 46. Treating psychosis in users of synthetic cannabinoids T. Klimenko and Svetlana Shakhova X. Resources 47. Cannabis and Web based Resources Rajkumar Rajendram Medicinal Usage of Cannabis and Cannabinoids I. Setting the scene and introductory chapters 1. How medical cannabis may influence the future of medicine Martha ROSENTHAL 2. Medical cannabis and cannabinoids: how best to extract components from plant material Daniela De Vita, Valentina Noemi Madia and Roberta Costi 3. Medicinal usage of cannabis and its impact on mental health among cancer patients and survivors Nicolas Hernandez Ortega, Ye Chen, Jessica Y. Islam, Diane Rodriguez, Marlene Camacho-Rivera and D.C. Vidot 4. Cannabis sativa as a traditional phytomedicine: a new narrative covering different countries M.N. Ahmed, Tridib Paul, Md. Nur Kabidul Azam, Rownak Jahan and Mohammed Rahmatullah 5. Medical use of cannabis in the middle east Bader Hamza Shirah, Mohammed Ahmed and Ruba Saleh 6. What medicinal cannabis is used for: a focus on Canada Dean T. Eurich, Cerina Lee and Jason Dyck 7. New York perspectives of medical cannabis laboratory analysis Lingyun Li, Stacey Chmura, Christopher Judd and Bryan C. Duffy 8. Epigenetic regulations on the quality of clonal cannabis plants: secondary metabolites and profiles Mohsen Hesami and Max Jones 9. Aberrant use of medicinal cannabis: theoretical and empirical considerations Daniel Feingold 10. Profile of older users of medical cannabis and cannabinoids Joshua Brown 11. Use of cannabidiol oil by caregivers: a focus on Alzheimer`s disease Magdalena Leszko 12. Medicinal use of cannabis: adverse events as a balanced perspective Giada Crescioli, Valentina Maggini, Fabio Firenzuoli, Alfredo Vannacci and Niccolo Lombardi II. Physiological aspects and metabolic aspects 13. Physiopathology and use of cannabinoids for fibrotic diseases Carmen del Rio and E. Munoz 14. Cannabinoids in inflammation and atherosclerosis Leonor Thomson, Edward Moreira-Bahnson and Bruno Musetti 15. Targeting the CB(2) receptors and other endocannabinoid elements to delay disease progression in cardiovascular diseases Shreesh Ojha 16. BMI in cannabis users: regulation, mechanisms and public health impact Thomas Clark III. Neurological, psychological and behavioural aspects 17. Neuroprotection by cannabis related products, cannabidiol and cannabigerol, and associated mechanisms of action Carolina Echeverry Sr., Jimena Fagetti, Miguel Reyes-Parada and Cecilia Scorza 18. Cannabis terpenes as neuroprotective agents: a focus on alpha-bisabolol John Staton Laws, Srijan Shrestha and Scott D. Smid 19. Cannabidiol in medicinal usage of stress: modelling investigations into cocaine M. Julia García-Fuster and Olga Valverde 20. Medicinal cannabis and neurocognition impairment Caroline MacCallum, April Christiansen, Lindsay Lo, Carly Pistawka, Michael Boivin and Melissa Snider-Adler 21. Genetic models of audiogenic seizures: what they are and how cannabinoids and Cannabis-derived compounds can be used to alleviate their symptoms - an updated narrative Norberto Garcia-Cairasco 22. Addressing the validity of cannabinoid therapy as an option for the treatment of substance use disorder Rose Chesworth, Erin McLemon and Tim Karl IV. Pharmacological and cellular aspects 23. Cannabidiolic acid (CBDA), features and profiles: anti-hyperalgesic effects G. Singh, Katja Linher-Melville and Raphael Mechoulam 24. Cannabis-drug interactions: implications for medicinal cannabis use Fran Gengo, Anna Mattle and Christopher Ralyea 25. Cannabinoid receptor subtype 2 (CB2R): features and targets for medical applications Marialessandra Contino, Carmen Abate, Nicola Antonio Colabufo, Francesco Leonetti and Angela Stefanachi 26. Medical use of cannabidiol and impact on cancer cell viability ` Kent E. Chair and Wesley Raup-Konsavage 27. Anti-inflammatory and antioxidant and immunomodulatory effects of phytocannabinoid -caryophyllene: A mechanistic overview Vafa Baradaran Rahimi, Arghavan Memarzia and Prof. Vahid Reza Askari V. Symptom Control and Medicinal Uses 28. Cancer patients and providers: Attitudes and beliefs of cannabis and cannabinoids use as a treatment Kimberson Tanco 29. CBD (cannabidiol) use in breast cancer chemotherapy Ana I. Torres-Suarez, Ana Isabel Fraguas-Sánchez and Ana Fernández-Carballido 30. Sleep: cannabis and cannabinoids use Eric Murillo-Rodríguez 31. Cannabis and cannabis related products and their uses in aiding sexual health of men and women Lynnette Nathalie Lyzwinski 32. Symptom control in palliative care settings: The role of cannabis-based medicines Leah Sera and Maximillian Stevenson 33. Cannabidiol (CBD) Use in Fragile X Spectrum Disorders Devon Johnson and Randi J. Hagerman 34. Hempseed (Cannabis sativa) and ameliorative effects in hypercholesterolemia Naveen Kaushal 35. Benzodiazepines and cannabis use C. Purcell 36. Features of (+)-trans-cannabidiol-2-hydroxy pentyland applications to disease: a focus on usage in diabetic nephropathy E. Munoz, Matthias Winkler, Marcus Goetz and Isabel Gonzalez Mariscal 37. Medical use of cannabis: applications to Tourette syndrome Kirsten R. Müller-Vahl and Natalia Szejko 38. Cannabinoids and their use in chronic non-cancer pain: a new narrative review Stanley Sau-Ching Wong and Chi Wai Cheung 39. Endometriosis: features and potential role of medical cannabis Mike Armour and Justin Sinclair 40. Cannabis usage for Crohn`s disease and ulcerative colitis: a narrative Joseph Feuerstein and Rajsavi Anand 41. Medical cannabis and use in migraine Jessica Jiang and Alasdair M. Barr 42. Cannabidiol (CBD ) and potential in medicinal use in rheumatoid arthritis Torsten Lowin 43. Role of Cannabinoids in Glaucoma: Lowering Intraocular Pressure or Neuroprotection Ujendra Kumar, Sneha Singh and Rishi Somvanshi 44. Medicinal potential of anandamide as a representative endocannabinoid and its effect at the cellular level in skin Adrianna Maria Piasek and Anna Sobiepanek VI. Resources 45. Medical Cannabis and Resources Rajkumar Rajendram Neurobiology, Physiology, And The Endocannabinoid System I. Setting the scene and introductory chapters 1. Distribution of the endocannabinoid system: linking signalling and development Michaela Dvorakova and Anna Kalinovsky 2. The endocannabinoid system, immunomodulation, and LPS-induced inflammation Elliot Lloyd, Nina Nguyen and Judith Hellman 3. Physiology of the endocannabinoid systems: imaging and the use of positron emission tomography (PET) Claudia Poluga, Cassis Varlow, Neil Vasdev, Isabelle Boileau and Laura M. Best 4. The endocannabinoid system and aging Prof. Vahid Reza Askari 5. The endocannabinoid system and post traumatic stress disorder (PTSD): a new narrative Luke Ney, Kevin Crombie and Leah M. Mayo II. Neurobiology of the endocannabinoid system 6. The protective effect of the endocannabinoid system in neurotoxin induced damage to hippocampal neurons: a focus on light and electron microscopy Rita Yakovlevna Gordon, Valentina Kitchigina and Irina Mikheeva 7. Endocannabinoid Signaling and excitatory and inhibitory synapses Jian Liang and Corette J. Wierenga 8. The endocannabinoids and potassium channels: an updated narrative Yu-Fung Lin 9. Social interactions and neural activity: linking cellular studies and endocannabinoid signalling Cheryl McCormick 10. Exercise and Parkinson`s disease: linking in the cannabinoid type 1 (CB1) and type 2 (CB2), and mu-opioid receptors Marucia Chacur Sr., Caroline Cristiano Real Gregório and Karina Henrique Binda 11. The endocannabinoids system and endocannabinoid receptors in sleep Nasreen Akhtar 12. Endocannabinoids and inhalant misuse: neuropsychological aspects John Woodward 13. Fatty acid amide hydrolase (FAAH) in substance use disorders: FAAH regulation and inhibition in cannabis, alcohol, nicotine, stimulant, and opioid use disorders Garth E. Terry and Greta Niemela 14. Treatment of pain with dual fatty acid amide hydrolase (FAAH) enzyme and human soluble epoxide hydrolase (sEH) enzyme inhibitors: interlinking the endocannabinoid system Stevan Pecic and Ram Kandasamy 15. WWL70: linking the hydrolyses 2-arachidonoylglycerol, endocannabinoid and eicosanoid pathways: therapeutic potential and neurological disease Mikiei Tanaka and Yumin Zhang 16. Endocannabinoid catabolic enzyme inhibitors and pain alleviation Sidney Stevens Negus and Clare Diester 17. The endocannabinoid system in health and disease: features in epilepsy Christopher Martínez-Aguirre, Maria de los Angeles Nuñez-Lumbreras and Luisa Lilia Rocha 18. The endocannabinoid system and autoimmune demyelination: a focus on multiple sclerosis Ana Bernal-Chico, Andres Baraibar, Alvaro Moreno-Garcia, Teresa Colomer, Ester Sanchez, Carmen Utrilla, Carlos Matute and Susana Mato 19. Endocannabinoid signaling and the lateral habenula Jiang-Hong Ye 20. On the interplay among endocannabinoid, noradrenergic and glucocorticoid systems: evidence from aversive memory studies Moisés Dos Santos Corrêa, Raquel Fornari, Cristina A. Stern, Leandro José Bertoglio and Lucas Gazarini III. Receptor biology and responses 21. Adenosine A2A-cannabinoid CB1 receptor heteromers in the brain: From trans-inhibition to trans-activation Ester Aso and Francisco Ciruela 22. Hippocampal CB1, CB2 receptors, the endocannabinoid system and fear memory Ana Maria Raymundi and Cristina A. Stern 23. Beta-caryophyllene, the CB2 cannabinoid receptor-specific agonists and wound healing Prof. S. Koyama 24. The nigrostriatal dopaminergic pathway: impact of WIN 55212-2 as a potent cannaboinoid receptor agonist Enzo Perez-Valenzuela and Jose Antonio Fuentealba Evans 25. Peripheral cannabinoid receptor 1 antagonists and impact on adipocytes Morvarid Kabir 26. Endocannabinoid system receptors in plasma membranes : extraction, lipid rafts and the cortex Changiz Taghibiglou and Hajar Miranzadeh Mahabadi 27. Applications to wound healing: cannabinoid receptor 1 antagonism and collagen deposition Inês Correia-Sa 28. Role of the Transient Receptor Potential Vanilloid 1 (TRPV1), a component of the endocannabinoid system, in anxiety, depression, and cocaine addiction Carmen S. Maldonado-Vlaar and Wickensonn Norze 29. Allosteric modulators of the endocannabinoid system: Org27569 and cannabinoid receptor 1 (CB1) Dai Lu 30. Naturally occurring DELTA-9-tetrahydrocannabinol-derivatives and binding to CB1 and CB2 receptors: Linking in the endocannabinoid system Irene Reyes-Resina, Rafael Rivas-Santisteban, Iu Raïch, Claudia Llinás del Torrent, Jaume Lillo, Rafael Franco and Gemma Navarro IV. Profiles and behaviour of selective endocannabinoids 31. New cannabinoid receptor type 1 and 2 agonists and applications to understanding the endocannabinoid system Manuel Faundez-Parraguez 32. Fatty acid amide hydrolase, the endocannabinoid anandamide and neurological disease Filomena Fezza 33. The endocannabinoid-system in the immuno-biology of dendritic cells Dipyaman Ganguly 34. Palmitoylethanolamide and other anandamide congeners in neuroinflammation-based disorders: linking in the endocannabinoid system Enza Palazzo 35. Endocannabinoid modulation of synaptic function and behavior in the dorsomedial hypothalamus Karen M. Crosby 36. Key role of anandamide and the endocannabinoid system in the modulation of cardio-renal homeostasis Prof. Virna M. Martín Gimenez and Walter Manucha 37. The endocannabinoid system: Signaling and social motivation Roberta Monterazzo Cysneiros and Fernanda Ribeiro V. Exogenous, synthetic other compounds linking in the endocannabinoid system 38. Safety and toxicology of the dietary cannabinoid beta-caryophyllene Prof. George Oliveira Sr., Bruna Silva, Ana Santos C. L. da Silva and Luciano Silva Lopes 39. Synthetic cannabimimetics: an overview Prof. M. Kassiou VI. Compartive studies in non neurological systems 40. Non Neurological Aspects of the Endocannabinoid System: Non Alcoholic Fatty Liver Disease Dr. R. Ghazali 41. Components of the Endocannabinoid system: Hepatic expression levels of the cannabinoid receptors and microRNAs Sema Bolkent and Zeynep Mine Coskun 42. Tumour growth and the endocannabinoid system: investigating CB2 agonists Josee Guindon, Isabel Castro-Piedras, Melissa McHann and Robert Barnes 43. Linking Endocannabinoid System, Palmitoylethanolamide and Sarcopenia in view of therapeutic outcomes Susanna Molinari, Eleonora Maretti, Renata Battini and Eliana Leo VII. Resources 44. Endocannabinoids and Resources Rajkumar Rajendram |