Diagnostic Pathology: Infectious Diseases, 3rd Edition

Description:

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of infectious diseases, including novel infections and lesser-known microorganisms, this volume incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Infectious Diseases is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.

Features:

• Covers all areas of infectious disease pathology, with chapters on the most to least common infections of the central nervous system, head and neck, and skin/soft tissue, as well as on the pulmonary, cardiac, gastrointestinal, genitourinary, and gynecologic systems

• Includes new chapters on COVID-19 and Mpox; eight new helminth chapters; additional new fungal chapters; a new, detailed tick identification chapter; an updated biosafety chapter; and more

• Contains significantly updated information throughout, including new content on artificial intelligence, whole-slide and mass spectrometry imaging, and metagenomic next-generation sequencing

• Discusses the best approach for diagnostic work-up and addresses the challenges in maximizing diagnostic yield while avoiding misinterpretation of results that could lead to false positives

• Details the increasing use of molecular diagnostics in infectious disease pathology

• Provides updates on taxonomy and nomenclature across all classes of infectious microorganisms (bacteria, fungi, parasites, viruses) along with new genomic data

• Features more than 1,400 images, including histology and gross pathology images, full-color medical illustrations, clinical photographs, and radiology images to help practicing and in-training pathologists reach a confident diagnosis

• Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care

• Includes an eBook version?that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud

• Table Of Contents:

• SECTION 1: OVERVIEW

  4 Standard Methods for Infectious Diseases

  Zoe Weiss, MD, Nicole Pecora, MD, PhD, and Shira Winters, MD

  10 Emerging Techniques

  Jessica Crothers, MD

  14 Biosafety Considerations

  Jessica Crothers, MD

  18 Pitfalls and Artifacts

  Jessica Crothers, MD

  OVERVIEW OF INFECTIONS BY ORGAN SYSTEM

  22 Central and Peripheral Nervous System Infections

  Isaac Solomon, MD, PhD

  26 Cardiovascular System Infections

  Jessica Crothers, MD

  30 Respiratory System Infections

  Jessica Crothers, MD

  34 Gastrointestinal System Infections

  Jessica Crothers, MD

  38 Genitourinary System Infections

  Jessica Crothers, MD

  42 Skin, Soft Tissue, and Bone Infections

  Alvaro Laga, MD, MSc

  SECTION 2: VIRAL INFECTIONS

  DNA VIRUSES48 Herpes Simplex Virus 1 and 2 (HSV-1, HSV-2) Infections

  Isaac Solomon, MD, PhD, Leigh Compton, MD, and Dan A. Milner, MSc(Epi), MBA

  54 Varicella-Zoster Virus (HHV-3) Infections

  Isaac Solomon, MD, PhD, Eleanor Russell-Goldman, MD, PhD, and Dan A. Milner, MSc(Epi), MBA

  58 Epstein-Barr Virus (HHV-4) Infection

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  64 Cytomegalovirus (HHV-5) Infections

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  70 Human Herpesvirus 6 and 7 (HHV-6, HHV-7) Infections

  Isaac Solomon, MD, PhD

  72 Kaposi Sarcoma-Associated Herpesvirus (HHV-8) Infection

  Isaac Solomon, MD, PhD, Leigh Compton, MD, and Dan A. Milner, MSc(Epi), MBA

  78 Herpes B Virus Infection

  Isaac Solomon, MD, PhD

  80 Adenovirus Infection

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  84 Hepatitis B and D Virus Infections

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  88 Measles Virus Infection

  Isaac Solomon, MD, PhD

  90 Parvovirus B19 Infection

  Isaac Solomon, MD, PhD, Leigh Compton, MD, and Dan A. Milner, MSc(Epi), MBA

  94 JC Virus, BK Virus, and Other Polyomavirus Infections

  Isaac Solomon, MD, PhD

  100 Monkeypox and Other Pox Virus Infections

  Alvaro Laga, MD, MSc, Dan A. Milner, MSc(Epi), MBA, and Isaac Solomon, MD, PhD

  104 Molluscum Contagiosum

  Isaac Solomon, MD, PhD

  106 Human Papillomavirus Infection

  Dan A. Milner, MSc(Epi), MBA and T. Rinda Soong, MD, PhD, MPH

   

  RNA VIRUSES116 Arbovirus Infections

  Isaac Solomon, MD, PhD

  122 Zika Virus Infection

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  126 Ebola, Marburg, and Other Hemorrhagic Fever Virus Infections

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  132 Enterovirus Infection

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  134 Poliovirus Infection

  Jessica Crothers, MD and Isaac Solomon, MD, PhD

  136 Rabies Virus Infection

  Isaac Solomon, MD, PhD

  138 Lymphocytic Choriomeningitis Virus Infection

  Isaac Solomon, MD, PhD

  140 Mumps Virus Infection

  Isaac Solomon, MD, PhD

  142 Rubella Virus Infection

  Isaac Solomon, MD, PhD

  144 Human Immunodeficiency Virus Infection

  Dan A. Milner, MSc(Epi), MBA

  148 Human T-Lymphotropic Virus Type I Infection

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  150 Influenza Virus Infections

  Isaac Solomon, MD, PhD

  154 Parainfluenza Virus Infections

  Isaac Solomon, MD, PhD

  156 Coronavirus Disease 2019 (COVID-19)

  Isaac Solomon, MD, PhD

  162 Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Other Coronavirus Infections

  Isaac Solomon, MD, PhD

  164 Respiratory Syncytial Virus Infection

  Isaac Solomon, MD, PhD and Eleanor Russell-Goldman, MD, PhD

  166 Rhinovirus, Human Metapneumovirus, and Other Respiratory Virus Infections

  Isaac Solomon, MD, PhD

  168 Rotavirus, Norovirus, and Astrovirus Infections

  Isaac Solomon, MD, PhD

  170 Hepatitis A and E Virus Infections

  Isaac Solomon, MD, PhD

  174 Hepatitis C Virus Infection

  Isaac Solomon, MD, PhD, Eleanor Russell-Goldman, MD, PhD, and Dan A. Milner, MSc(Epi), MBA

   

  SECTION 3: PRION DISEASES180 Transmissible Spongiform Encephalopathies

  Isaac Solomon, MD, PhDSECTION 4: BACTERIAL INFECTIONS186 Bacterial Infections

  Nicole Pecora, MD, PhD

  188 Botryomycosis

  Malak Abedalthagafi, MD, MBA

  190 Malakoplakia

  Malak Abedalthagafi, MD, MBA and Leigh Compton, MD

   

  GRAM-POSITIVE BACTERIA192 Actinomycosis

  Nicole Pecora, MD, PhD, Leigh Compton, MD, and Dan A. Milner, MSc(Epi), MBA

  194 Bacillus Species Infections

  Zoe Weiss, MD and Nicole Pecora, MD, PhD

  198 Corynebacterium Species Infections

  Nicole Pecora, MD, PhD

  202 Listeria Species Infection

  Zoe Weiss, MD and Nicole Pecora, MD, PhD

  204 Rhodococcus Species Infection

  Zoe Weiss, MD and Nicole Pecora, MD, PhD

  206 Clostridioides and Other Gram-Positive Anaerobes

  Nicole Pecora, MD, PhD and Zoe Weiss, MD

  210 Staphylococcus Species Infections

  Zoe Weiss, MD and Nicole Pecora, MD, PhD

  216 Streptococcus and Enterococcus Species Infections

  Zoe Weiss, MD and Nicole Pecora, MD, PhD

  220 Whipple Disease

  Jessica Crothers, MD, Dan A. Milner, MSc(Epi), MBA, and Isaac Solomon, MD, PhD

   

  GRAM-NEGATIVE BACTERIA224 Pathologically Important Enterobacteriaceae

  Nicole Pecora, MD, PhD

  232 Fastidious Organisms

  Nicole Pecora, MD, PhD

  238 Nonfermentative Organisms

  Zoe Weiss, MD, Nicole Pecora, MD, PhD, and Lenette Lu, MD, PhD

  244 Gram-Negative Anaerobes

  Zoe Weiss, MD and Nicole Pecora, MD, PhD

  248 Neisseria and Moraxella Species Infections

  Nicole Pecora, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  252 Pertussis

  Dan A. Milner, MSc(Epi), MBA

  254 Helicobacteriosis

  Dan A. Milner, MSc(Epi), MBA

  256 Spirochetosis

  Nicole Pecora, MD, PhD, Leigh Compton, MD, and Dan A. Milner, MSc(Epi), MBA

  258 Borrelia Species Infections

  Nicole Pecora, MD, PhD

  262 Leptospira Species Infection

  Nicole Pecora, MD, PhD

  264 Syphilis and Other Treponematoses

  Alvaro Laga, MD, MSc, Malak Abedalthagafi, MD, MBA, and Dan A. Milner, MSc(Epi), MBA

  268 Campylobacter and Vibrio Species Infections

  Zoe Weiss, MD and Nicole Pecora, MD, PhD

  272 Anaplasmosis and Ehrlichiosis

  Nicole Pecora, MD, PhD, Lenette Lu, MD, PhD, and Dan A. Milner, MSc(Epi), MBA

  276 Chlamydophila and Chlamydia Species Infections

  Nicole Pecora, MD, PhD

  280 Mycoplasma and Ureaplasma Species Infections

  Zoe Weiss, MD and Isaac Solomon, MD, PhD

  282 Rickettsia Species Infection

  Nicole Pecora, MD, PhD

  286 Coxiella Species Infection

  Nicole Pecora, MD, PhD

   

  ACID-FAST BACTERIA290 Mycobacterium tuberculosis Complex Infections

  Nicole Pecora, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  296 Leprosy

  Malak Abedalthagafi, MD, MBA and Dan A. Milner, MSc(Epi), MBA

  300 Buruli Ulcer

  Alvaro Laga, MD, MSc

  304 Other Mycobacterial Infections

  Nicole Pecora, MD, PhD

  308 Nocardiosis

  Dan A. Milner, MSc(Epi), MBA

   

  SECTION 5: FUNGAL INFECTIONS314 Fungal Classification and Diagnosis

  Jessica Crothers, MD and Dan A. Milner, MSc(Epi), MBAMOLDS

  318 Aspergillosis

  Zoe Weiss, MD, Alvaro Laga, MD, MSc, and Isaac Solomon, MD, PhD

  324 Entomophthoramycosis

  Alvaro Laga, MD, MSc

  328 Fusariosis and Other Hyalohyphomycoses

  Zoe Weiss, MD, Alvaro Laga, MD, MSc, and Nicole Pecora, MD, PhD

  330 Lobomycosis

  Alvaro Laga, MD, MSc

  334 Mucormycosis

  Zoe Weiss, MD, Alvaro Laga, MD, MSc, and Isaac Solomon, MD, PhD

  338 Mycetoma

  Alvaro Laga, MD, MSc, T. Rinda Soong, MD, PhD, MPH, and Brian J. Hall, MD

  342 Phaeohyphomycosis

  Alvaro Laga, MD, MSc, Dan A. Milner, MSc(Epi), MBA, and Isaac Solomon, MD, PhD

  344 Rhinosporidiosis

  Alvaro Laga, MD, MSc and T. Rinda Soong, MD, PhD, MPH

  346 Scedosporiosis

  Alvaro Laga, MD, MSc, Zoe Weiss, MD, and Eleanor Russell-Goldman, MD, PhD

  348 Scopulariopsis Infections

  Zoe Weiss, MD, Alvaro Laga, MD, MSc, and Eleanor Russell-Goldman, MD, PhD

  350 Sporotrichosis

  Alvaro Laga, MD, MSc and Dan A. Milner, MSc(Epi), MBA

  354 Tineasis

  Malak Abedalthagafi, MD, MBA, Leigh Compton, MD, and Isaac Solomon, MD, PhD

  356 Trichosporonosis

  Alvaro Laga, MD, MSc, Dan A. Milner, MSc(Epi), MBA, and Isaac Solomon, MD, PhD

  360 Superficial Mycoses

  Alvaro Laga, MD, MSc

   

  YEAST AND YEAST-LIKE ORGANISMS

  364 Blastomycosis

  Jessica Crothers, MD

  370 Candidiasis

  Jessica Crothers, MD, T. Rinda Soong, MD, PhD, MPH, and Isaac Solomon, MD, PhD

  374 Chromoblastomycosis

  Alvaro Laga, MD, MSc, T. Rinda Soong, MD, PhD, MPH, and Nicole Pecora, MD, PhD

  378 Coccidioidomycosis

  Malak Abedalthagafi, MD, MBA and Isaac Solomon, MD, PhD

  380 Cryptococcosis

  Alvaro Laga, MD, MSc, T. Rinda Soong, MD, PhD, MPH, and Isaac Solomon, MD, PhD

  386 Histoplasmosis

  Alvaro Laga, MD, MSc, T. Rinda Soong, MD, PhD, MPH, and Nicole Pecora, MD, PhD

  392 Paracoccidioidomycosis

  Alvaro Laga, MD, MSc, Eleanor Russell-Goldman, MD, PhD, and Isaac Solomon, MD, PhD

  394 Penicilliosis

  Alvaro Laga, MD, MSc, Dan A. Milner, MSc(Epi), MBA, and Isaac Solomon, MD, PhD

  396 Pneumocystosis

  Jessica Crothers, MD, Eleanor Russell-Goldman, MD, PhD, and Dan A. Milner, MSc(Epi), MBA

  400 Protothecosis

  Jessica Crothers, MD

   

  SECTION 6: PROTOZOAN PARASITIC INFECTIONS

  406 Protozoa Classification and Diagnosis

  Dan A. Milner, MSc(Epi), MBA

   

  GASTROINTESTINAL AND OTHER LUMINAL PROTOZOA

  408 Balantidiasis

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  410 Cryptosporidiosis and Other Coccidia Infections

  Malak Abedalthagafi, MD, MBA and Dan A. Milner, MSc(Epi), MBA

  414 Entamebiasis

  Malak Abedalthagafi, MD, MBA

  418 Giardiasis

  Malak Abedalthagafi, MD, MBA, Eleanor Russell-Goldman, MD, PhD, and Dan A. Milner, MSc(Epi), MBA

  420 Microsporidiosis

  Malak Abedalthagafi, MD, MBA and Dan A. Milner, MSc(Epi), MBA

  422 Trichomoniasis

  Alvaro Laga, MD, MSc and T. Rinda Soong, MD, PhD, MPH

   

  INTRAVASCULAR PROTOZOA

  424 African Trypanosomiasis

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  426 Babesiosis

  Malak Abedalthagafi, MD, MBA, Dan A. Milner, MSc(Epi), MBA, and Lenette Lu, MD, PhD

  430 Malaria

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

   

  DEEP TISSUE PROTOZOA

  436 Free-Living Amebiasis

  Alvaro Laga, MD, MSc, Isaac Solomon, MD, PhD, and Dan A. Milner, MSc(Epi), MBA

  442 American Trypanosomiasis

  Malak Abedalthagafi, MD, MBA, Eleanor Russell- Goldman, MD, PhD, and Dan A. Milner, MSc(Epi), MBA

  444 Leishmaniasis

  Malak Abedalthagafi, MD, MBA and Dan A. Milner, MSc(Epi), MBA

  448 Toxoplasmosis

  Malak Abedalthagafi, MD, MBA and Dan A. Milner, MSc(Epi), MBA

   

  SECTION 7: HELMINTHIC PARASITIC INFECTIONS

   

  NEMATODES

  454 Ancylostomiasis and Necatoriasis

  Dan A. Milner, MSc(Epi), MBA

  456 Angiostrongyliasis

  Isaac Solomon, MD, PhD

  458 Ascariasis

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  462 Enterobiasis

  Jessica Crothers, MD

  466 Gnathostomiasis

  Alvaro Laga, MD, MSc

  468 Human Filariasis

  Malak Abedalthagafi, MD, MBA, Isaac Solomon, MD, PhD, and Eleanor Russell-Goldman, MD, PhD

  472 Onchocerciasis

  Malak Abedalthagafi, MD, MBA

  474 Strongyloidiasis

  Malak Abedalthagafi, MD, MBA and Isaac Solomon, MD, PhD

  478 Trichuriasis

  Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA

  482 Trichinellosis

  Jessica Crothers, MD

  484 Other Tissue Nematode Infections

  Dan A. Milner, MSc(Epi), MBA

   

  TREMATODES

  488 Clonorchiasis and Opisthorchiasis

  Jessica Crothers, MD

  492 Fascioliasis and Fasciolopsiasis

  Jessica Crothers, MD

  494 Paragonimiasis

  Jessica Crothers, MD

  496 Schistosomiasis

  Dan A. Milner, MSc(Epi), MBA and Isaac Solomon, MD, PhD

   

  CESTODES

  502 Coenurosis

  Isaac Solomon, MD, PhD

  504 Cysticercosis

  Isaac Solomon, MD, PhD

  510 Diphyllobothriasis

  Jessica Crothers, MD

  514 Echinococcosis

  Dan A. Milner, MSc(Epi), MBA and Isaac Solomon, MD, PhD

  SECTION 8: INFESTATIONS AND OTHER INVERTEBRATE-RELATED MALADIES

  520 Tick Identification

  Alvaro Laga, MD, MSc

  524 Tissue Damage From Arachnids and Insects

  Alvaro Laga, MD, MSc and Dan A. Milner, MSc(Epi), MBA

  532 Myiasis

  Malak Abedalthagafi, MD, MBA and Dan A. Milner, MSc(Epi), MBA

  534 Scabies

  Malak Abedalthagafi, MD, MBA, Leigh Compton, MD, and Dan A. Milner, MSc(Epi), MBA

  536 Demodex Infestations

  Malak Abedalthagafi, MD, MBA and Dan A. Milner, MSc(Epi), MBA

  538 Tungiasis

  Malak Abedalthagafi, MD, MBA and Dan A. Milner, MSc(Epi), MBA