Diagnostic Pathology: Blood and Bone Marrow, 3rd Edition

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of blood and bone marrow, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Blood and Bone Marrow is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, oncologist, hematologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.

• Provides practicing pathologists with key details about new entities, newly recognized causes of morphologic change in blood and bone marrow abnormalities, and new strategies for appropriate workup of neoplastic processes―all with a focus on key tests and key differential diagnostic considerations

• Helps pathologists recognize unique blood and bone marrow findings that can be an indicator for specific exposures, such as new medications, new targeted therapies, or toxins

• Integrates updated technologies, newly recognized disorders, complications/features in blood and bone marrow, new targeted therapies, and the increased use of homeopathic remedies

• Contains new chapters covering SARS-CoV-2 infection features in blood and bone marrow, myelodysplastic syndrome (MDS) mimics, blood and bone marrow findings linked to targeted therapies, blood and bone marrow findings linked to other medications, and more

• Updates all existing chapters and contains expanded information on T-cell neoplasms in blood and bone marrow and intravascular large B-cell lymphoma in blood and bone marrow

• Includes details from the World Health Organization (WHO) fifth edition Classification of Haematolymphoid Tumours and the very latest 2023 International Consensus Classification (ICC) publications, reflecting new and renamed diagnostic entities, tumor classification changes and updates, and terminology changes and updates

• Discusses molecular testing strategies based on specific neoplasms and specific differential diagnostic consideration

• Clearly delineates numerous genetic disorders often found in blood and bone marrow

• Features more than 2,500 superb images, including histology and gross pathology photographs, full-color illustrations and graphics, clinical photographs and radiologic images, and many new tables and charts/algorithms

• Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care

• Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

• 2 Introduction     
  3  Hematopoiesis and Bone Marrow Histology     
  4  Bone Marrow Examination and Techniques     
  5  Synoptic Bone Marrow Reporting     
  6  Overview of Constitutional and Acquired Bone Marrow Disorders     
  7 Anemia      
  8  Overview of Anemia     
  9  Acquired Anemias     
  10   Anemias of Inflammation, Chronic Renal Disease, and Cancer    
  11   Iron Deficiency Anemia    
  12   Autoimmune Hemolytic Anemias    
  13   Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn    
  14   Microangiopathic Hemolytic Anemia    
  15   Megaloblastic Anemia    
  16   Acquired Nonneoplastic Sideroblastic Anemia    
  17   Alcoholism-Associated Anemia    
  18   Anemia in the Elderly    
  19   Copper Deficiency-Associated Anemia    
  20   Acquired Red Cell Aplasia    
  21   Transient Erythroblastopenia of Childhood    
  22   Parvovirus-Induced Red Cell Aplasia    
  23   Paroxysmal Nocturnal Hemoglobinuria    
  24   Acquired Aplastic Anemia    
  25  Constitutional Anemias     
  26   Thalassemia    
  27   Sickle Cell Anemia    
  28   Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency    
  29   Pyruvate Kinase Deficiency    
  30   Hereditary Spherocytosis    
  31   Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis    
  32   Diamond-Blackfan Anemia    
  33   Fanconi Anemia    
  34   Congenital Dyserythropoietic Anemia    
  35   Congenital Sideroblastic Anemia    
  36   Congenital Megaloblastic Anemia    
  37 Erythrocytosis      
  38  Constitutional     
  39   Congenital Erythrocytosis    
  40  Acquired     
  41   Acquired Erythrocytosis    
  42 Benign Leukocyte Disorders in Blood and Bone Marrow      
  43  Overview of Benign Leukocyte Disorders in Blood and Bone Marrow     
  44  Pancytopenia     
  45  Neutropenia     
  46  Neutrophilia     
  47  Monocytosis     
  48  Eosinophilia     
  49  Basophilia     
  50  Lymphocytosis     
  51  Lymphopenia, Constitutional and Acquired     
  52  Plasmacytosis of Bone Marrow     
  53  Hematogones in Bone Marrow     
  54  Lymphoid Aggregates in Bone Marrow     
  55  Granulomas in Bone Marrow     
  56 Constitutional Granulocytic Disorders      
  57  Constitutional Neutropenias     
  58   Severe Congenital Neutropenia and Cyclic Neutropenia    
  59   Shwachman-Diamond Syndrome    
  60   Chediak-Higashi Syndrome    
  61   Myelokathexis in WHIM Syndrome    
  62  Constitutional Neutrophil Anomalies     
  63   Pelger-Huët Anomaly    
  64   *MYH9*-Related Disorders    
  65   Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation    
  66 Megakaryocytic Disorders      
  67  Overview of Megakaryocytic Disorders     
  68  Acquired Platelet Disorders With Thrombocytopenia     
  69   Immune-Mediated Thrombocytopenia    
  70   Hemolytic-Uremic Syndrome    
  71   Heparin-Induced Thrombocytopenia (HIT)    
  72   Thrombotic Thrombocytopenic Purpura    
  73   Pregnancy-Associated Thrombocytopenia    
  74  Constitutional Platelet Disorders With Thrombocytopenia     
  75   Macrothrombocytopenia    
  76   Thrombocytopenia Absent Radius Syndrome    
  77   Congenital Amegakaryocytic Thrombocytopenia    
  78   Gray Platelet Syndrome    
  79   Wiskott-Aldrich Syndrome-Related Disorders    
  80   Congenital Thrombotic Thrombocytopenic Purpura    
  81  Thrombocytosis     
  82   Thrombocytosis    
  83 Infection      
  84  Overview of Infection     
  85  Hantavirus Pulmonary Syndrome     
  86  Human Immunodeficiency Virus     
  87  Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus)     
  88  Parvovirus B19 Infection     
  89  Bacterial Infections, Blood and Bone Marrow Features     
  90  Fungal Infections, Blood and Bone Marrow Features     
  91  Helminthic Infections     
  92  Malaria     
  93  Other Protozoan Infections     
  94  COVID-19 Infection     
  95 Miscellaneous Nonneoplastic Disorders and Conditions      
  96  Overview and Classification of Hemophagocytic Disorders in Bone Marrow     
  97  Hematologic Manifestations of Collagen Vascular Disorders     
  98  Hematologic Manifestations of Chronic Renal Disorders     
  99  Lysosomal Storage Diseases With Predominantly Histiocytic Storage     
  100  Homeopathic Remedies and Medications Affecting Blood and Bone Marrow     
  101  Other Pregnancy-Associated Hematologic Disorders     
  102  VEXAS Syndrome     
  103  Gelatinous Transformation and Other Bone Marrow Stromal Disorders     
  104  Crystals in Bone Marrow     
  105  Bone Abnormalities in Bone Marrow Specimens     
  106 Myeloid Neoplasms      
  107  Overview and Classification of Myeloid Neoplasms     
  108  Specialized Testing in Myeloid Neoplasms     
  109  Clinical Practice Guidelines for Initial Work-Up of Acute Leukemia     
  110  Myeloproliferative Neoplasms     
  111   Overview of Myeloproliferative Neoplasms    
  112   Chronic Myeloid Leukemia, *BCR-ABL1* Positive    
  113   Chronic Neutrophilic Leukemia    
  114   Polycythemia Vera    
  115   Primary Myelofibrosis    
  116   Essential Thrombocythemia    
  117   Chronic Eosinophilic Leukemia, Not Otherwise Specified    
  118   Myeloproliferative Neoplasm, Unclassifiable    
  119  Mastocytosis     
  120   Systemic Mastocytosis    
  121   Mast Cell Leukemia    
  122  Myeloid and Lymphoid Neoplasms With Eosinophilia and Gene Rearrangements     
  123   Myeloid and Lymphoid Neoplasms With *PDGFRA* Rearrangement    
  124   Myeloid and Lymphoid Neoplasms With *PDGRFB* Rearrangement    
  125   Myeloid and Lymphoid Neoplasms With *FGFR1* Rearrangement    
  126   Myeloid and Lymphoid Neoplasms With *FLT3* Rearrangement    
  127  Myelodysplastic/Myeloproliferative Neoplasms     
  128   Overview of Myelodysplastic/Myeloproliferative Neoplasms    
  129   Chronic Myelomonocytic Leukemia    
  130   Atypical Chronic Myeloid Leukemia, *BCR-ABL1* Negative (aCML)    
  131   Juvenile Myelomonocytic Leukemia    
  132   Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis    
  133   Myelodysplastic/Myeloproliferative Neoplasms, Unclassifiable    
  134  Myelodysplastic Syndromes     
  135   Overview and Classification of Myelodysplastic Syndromes    
  136   Clonal Hematopoiesis of Indeterminant Potential (CHIP)    
  137   Myelodysplastic Syndrome With Single Lineage Dysplasia    
  138   Myelodysplastic Syndromes With Ring Sideroblasts    
  139   Myelodysplastic Syndrome With Multilineage Dysplasia    
  140   Myelodysplastic Syndromes With Excess Blasts    
  141   Myelodysplastic Syndrome With Isolated del(5q)    
  142   Myelodysplastic Syndrome, Unclassifiable    
  143   Childhood Myelodysplastic Syndrome (Refractory Cytopenia of Childhood)    
  144  Acute Myeloid Leukemia     
  145   Overview of Acute Myeloid Leukemia    
  146   Familial AML/MDS (Germline Predisposition)    
  147   Acute Myeloid Leukemia With t(8;21)(q22;q22.1), *RUNX1-RUNX1T1*    
  148   Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22), *CBFB-MYH11*    
  149   Acute Promyelocytic Leukemia With *PML-RARA*    
  150   Acute Promyelocytic Leukemia With Variant *RARA* Rearrangement    
  151   Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3), *KMT2A-MLLT3*    
  152   Subtypes of Acute Myeloid Leukemia: t(6;9), inv(3), t(1;22), t(9;22), Mutated *NPM1,* Biallelic Mutated *CEBPA,* Mutated *RUNX1*    
  153   Acute Myeloid Leukemia With Myelodysplasia-Related Changes    
  154   Therapy-Related Myeloid Neoplasms    
  155   Acute Myeloid Leukemia With Minimal Differentiation (AML, NOS)    
  156   Acute Myeloid Leukemia Without Maturation (AML, NOS)    
  157   Acute Myeloid Leukemia With Maturation (AML, NOS)    
  158   Acute Myelomonocytic Leukemia (AML, NOS)    
  159   Acute Monoblastic and Monocytic Leukemia (AML, NOS)    
  160   Pure Erythroid Leukemia (AML, NOS)    
  161   Acute Megakaryoblastic Leukemia, Not Otherwise Specified    
  162   Acute Basophilic Leukemia (AML, NOS)    
  163   Acute Panmyelosis With Myelofibrosis (AML, NOS)    
  164   Myeloid Proliferations Related to Down Syndrome    
  165   Measurable Residual Disease Testing Strategies in AML    
  166  Blastic Plasmacytoid Dendritic Cell Neoplasm     
  167   Blastic Plasmacytoid Dendritic Cell Neoplasm    
  168 Acute Leukemias of Ambiguous Lineage      
  169  Acute Undifferentiated Leukemia     
  170  Mixed Phenotype Acute Leukemia     
  171 Lymphoid Neoplasms      
  172  Overview of Lymphoid Neoplasms     
  173  Specialized Testing in Lymphoid Neoplasms     
  174  B-Precursor Neoplasms     
  175   B-Lymphoblastic Leukemia    
  176   Novel Genetic Subtypes of B-Lymphoblastic Leukemia    
  177   BCR-ABL1-Like ALL    
  178   Measurable Residual Disease Testing Strategies in ALL    
  179  T-Precursor Neoplasms     
  180   T-Lymphoblastic Leukemia/Lymphoma    
  181   Early T-Cell Precursor Acute Lymphoblastic Leukemia    
  182  Mature B-Cell Neoplasms     
  183   Overview and Classification of Mature B-Cell Leukemias, Immunosecretory Lymphomas    
  184   Monoclonal B-Cell Lymphocytosis    
  185   Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma    
  186   B-Cell Prolymphocytic Leukemia    
  187   Splenic Marginal Zone Lymphoma    
  188   Hairy Cell Leukemia    
  189   Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant    
  190   Lymphoplasmacytic Lymphoma    
  191   Gamma Heavy Chain Disease    
  192   Monoclonal Gammopathy of Undetermined Significance    
  193   Plasma Cell Myeloma    
  194   Burkitt Leukemia/Lymphoma    
  195   Mantle Cell Lymphoma in Blood and Bone Marrow    
  196   Follicular Lymphoma in Blood and Bone Marrow    
  197   Marginal Zone Lymphoma in Blood and Bone Marrow    
  198   Large B-Cell Lymphomas in Blood and Bone Marrow    
  199  Mature T-/NK-Cell Neoplasms     
  200   Overview and Classification of Mature T-/NK-Cell Neoplasms in Blood and Bone Marrow    
  201   T-Cell Prolymphocytic Leukemia    
  202   T-Cell Large Granular Lymphocytic Leukemia    
  203   Chronic Lymphoproliferative Disorder of NK Cells    
  204   Aggressive NK-Cell Leukemia    
  205   Adult T-Cell Leukemia    
  206   Mycosis Fungoides/Sézary Syndrome    
  207   Anaplastic Large Cell Lymphoma in Blood and Bone Marrow    
  208   Other T-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow    
  209  Hodgkin Lymphoma in Bone Marrow     
  210   Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte-Predominant Subtypes    
  211 Other Neoplasms Involving Bone Marrow      
  212  Langerhans Cell Histiocytosis in Bone Marrow     
  213  Posttransplant Lymphoproliferative Disorders in Bone Marrow     
  214  Metastatic Carcinoma and Sarcoma     
  215 CAP Protocol      
  216  Protocol for the Examination of Specimens from Patients with Non-Hodgkin Lymphoma/Lymphoid Neoplasms